Rebecca Naa Okaikor Akufo- Addo was born on the 12th of March 1951. She trained as a legal secretary and worked for prominent multinational law firms, including Clifford Chance and Ashurst Morris Crisp, in the United Kingdom.
She is a passionate philanthropist with a keen interest in issues that impact women and children. She is a founding member and chairperson of the charity, Infanta Malaria Prevention Foundation founded in 2005, to support the national effort to reduce malarial infections in infants and young children. Since 2017, the charity has added the eradication of malnutrition to its scope of work, having recognized the inter relation between malaria and malnutrition, particularly in children.
As First Lady she has established The Rebecca Foundation with a focus on the well-being of Ghanaian women and children through the implementation of sustainable, collaborative and high impact strategies. Education of children, the health of women and children and economic empowerment of women are the three main intervention areas under the Rebecca Foundation.
In response to avoidable deaths of women and children as a result of lack of space, the First lady has raised funds to construct a baby and mother unit at the second Tertiary health institution in Ghana- the Komfo Anokye Teaching Hospital; an initiative which will be extended to other parts of the country.
Mrs Rebecca Akufo-Addo is the premier ambassador for HIV/AIDS Advocacy, elimination of mother to child transmission as well as Empowerment of Young Women and Adolescent girls in Ghana, and is keen to ensure Ghana meets all its HIV/AIDS targets. As the West African Chair of the Organization of African First Ladies Against HIV/AIDS (OAFLA), she is committed to ensure that Africa is free from HIV / AIDS, and maternal and child mortality. She is a patron of the School for the Blind at Akropong in the Eastern region of Ghana and Cancer Voices, a Ghanaian coalition of Non-Governmental Organizations, against all cancers.
She is married to the President-Elect of the Republic of Ghana, Nana Addo Dankwa Akufo-Addo and they have five daughters and five grandchildren.
She loves floristry and also enjoys interior decoration.